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Nonetheless, administering a VEGF-upregulating compound to individuals with diagnosed or undiagnosed malignancies remains contraindicated based on precautionary clinical reasoning

Whatever the reason, the clinical development program ended

Side effects are rare but can include mild redness or soreness at the injection site

The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study