In type 2 diabetes, the reduced expression of HO-1 will increase the production of ROS, leading to oxidative stress and inflammatory reaction, further aggravating cell damage (Table 2)
In the pivotal 68-week trial of 1,961 adults, nausea and diarrhea were described as typically transient, mild-to-moderate in severity, and subsiding with time
The mechanism of action of Tirzepatide is dual compared with other weight loss medications because it acts on the GLP-1 and GIP receptors in charge of hunger regulation and glucose levels
Time-restricted eating, the most commonly studied fasting approach, produces weight loss primarily through reducing total caloric intake
It lowers FGF21, a hormone associated with metabolic stress, which might indicate reduced strain on the liver
Originally developed for type 2 diabetes, the GLP-1 class has been extensively studied for weight management