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Clinical trials such as SURPASS have demonstrated Tirzepatides ability to significantly reduce HbA1c levels (a marker of long-term blood glucose control) and induce substantial weight loss in patients with type 2 diabetes
Nonetheless, different animal models deficient for GLP-1 signaling, in addition to human studies, prove the dispensability of GLP-1 for surgical success ( On the other hand, PYY has been proven to be upregulated, and necessary, for RYGB mediated restoration of the diabetic islets, and overall cure of diabetes in rats (154)
Liu H, Deng Y, Li J, Lin W, Liu C, Yang X, et al
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Water retention may stack early on
10.2337/db14-1213 Diabetes
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