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Clinical Medicine Insights: Therapeutics, 12, 110

Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by [PMID: 28839430] Laboratory literature summary: Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

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Patients should: Follow the dose escalation schedule to minimise side effects Attend regular follow-up appointments to monitor progress and safety Engage with dietetic support to ensure adequate nutrition whilst reducing calorie intake Combine medication with increased physical activity (aim for 150 minutes moderate-intensity exercise weekly, plus muscle-strengthening activities on at least 2 days per week, as per UK Chief Medical Officers' guidelines) Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, physical activity, and behavioural strategies