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Back Eng, J, Kleinman, WA, Singh, L, et al (April 1992) 'Isolation and characterisation of Exendin-4, an Exendin-3 analogue, from heloderma suspectum venom', The Journal of Biological Chemistry , 267/11, 7402-06

The evidence is clear: KLOW administered during the cortisol peak produces higher lipolytic signaling, and KLOW administered during the GH pulse produces stronger anabolic partitioning

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The addition of glucagon receptor activation appears to be what pushes results beyond the 20% threshold that dual-agonists achieve

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The general tolerability profile observed across the phase 2 program is that of the incretin class: predominantly gastrointestinal adverse effects nausea, vomiting, diarrhea, constipation that are usually dose-related and most prominent during dose escalation