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Over time, this chronic immune activation may contribute to fatigue, cognitive changes, digestive disruption, respiratory symptoms, metabolic instability, and heightened inflammatory sensitivity

Boime and others have suggested that the formation of syncytia was linked to hCG production.16, 31 Observations consistent with this idea include the finding that isolated cytotrophoblast cells increase hCG secretion as they spontaneously fuse to form syncytial structures.32 However, the mononucleated trophectoderm of the blastocyst produces hCG before implantation, and the formation of syncytia and hCG expression can be dissociated in vitro.2 Therefore, the formation of a syncytium is not an absolute prerequisite for hCG expression, and the factors responsible for coupling trophoblast differentiation with synthesis of hCG remain obscure.16 hCG secretion may also be under the control of tropic factors

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10.2337/diacare.15.2.270 16