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In patients with type 2 DM, GLP-1R agonists have demonstrated a reduction in circumferential strain and improvement in markers of diastolic function, a key component of diabetic cardiomyopathy and the risk of developing heart failure
Nausea, vomiting, and diarrhoea can lead to fluid and electrolyte losses, reducing circulating blood volume and causing orthostatic hypotension (a drop in blood pressure upon standing)
"This is the Zygopush," Marvin tells me, while pressing his thumbs directly under his cheekbones and massaging upwards towards his ears in an attempt to hollow out his cheeks
Almost all patients (95%) were receiving cardiovascular medications (beta blockers, ACE inhibitors, angiotensin II receptor blockers, calcium channel blockers, nitrates, diuretics, aspirin, statins and fibrates)
Examples include semaglutide with oral (Rybelsus) and injectable (Ozempic) formulations, and dulaglutide (Trulicity), both with favorable cardiovascular outcomes data
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