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a fresh receptors output saturates below about 10% surface engagement (Gao 2023), so its near-flat acute signal is a snapshot, not the dose-response

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2.8.2 Human hepatocarcinoma cell line For cell viability in the human hepatocarcinoma cell line (HepG2), the 3-[4,5-dimethyl-thiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay was performed as previously described ( 2

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With a more detailed understanding of the pathophysiology of MDS and AML in the context of iron, future development of new iron-targeting strategies may lead to better patient outcomes