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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

Buckley and OMalley, n = 3 rats, p = 0.0264, Figure 1C)

As a result, patients with largely postprandial hyperglycaemia are more likely to benefit from treatment with short-acting GLP1-RAs as opposed to individuals with predominantly fasting hyperglycaemia, who would derive greater benefit from long-acting agents [52]