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Notably, commonly used cell culture media (for example, DMEM, RPMI and F12) contain supraphysiological levels of cystine but lack GSH and cysteinylglycine
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134 However, because of heterogeneity among cancer cells, other studies have shown that IDH2 expression is decreased in metastatic HCC and gastric cancer tissues compared with paired normal tissues
Emerging reproductive technologies, including mitochondrial replacement techniques, cytoplasmic transfer, and CRISPR-based approaches, offer potential strategies for restoring oocyte competence [47, 142,143,144]
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High levels of either substance could be a sign of PA
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