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La versin "no DAC" tiene una vida media ms corta, lo que permite una liberacin ms fisiolgica y controlada
Mechanism of Action Tolcapone works by inhibiting COMT enzyme, which normally metabolizes levodopa and dopamine
Clinicians should also avoid or adjust therapy in individuals with active peptic ulcer disease due to theoretical choline-mediated increases in gastric volume and in those receiving levodopa, as pantothenic-acid derivatives may interfere with levodopa absorption
E., Gul, M., Roy, S., and Sen, C
doi: 10.1007/s00262-019-02350-8 196 SekitaYWagatsumaHNakamuraKOnoRKagamiMWakisakaNet al
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