and the conversion of 5-methyltetrahydrofolate to tetrahydrofolate
Certain medications may also interfere with absorption and cause deficiency, in particular, medicines prescribed for heartburn, antibiotics, blood pressure medicine, cholesterol-lowering drugs, diabetes medications and antipsychotic drugs
Groups that may benefit include: Individuals with high energy demands due to work or exercise Those following vegan or vegetarian diets, which can be low in B12 Older adults, as B12 absorption can decrease with age B12 and Folic Acid Combination Injections Healthcare providers might suggest combination injections for low B12 and folic acid levels
Many people who receive vitamin B12 shots report feeling more energetic and less tired within days
A study published in the International Journal of Academic Medicine and Pharmacy had found the link between inadequate vitamin B12 levels and adverse health outcomes, including metabolic disorders and cardiovascular risk factors
ref2 : Messina M, Messina V