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Role of membrane transport in metabolism and function of glutathione in mammals

This heterogeneity and poorly understood neurobiology pose significant challenges to existing drug development paradigms, resulting in scarce treatment options, especially for bipolar depression

Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Weeks 13 and beyond: 8 to 12 mg once weekly (based on response and tolerance) This protocol reaches the therapeutic range in approximately 8 weeks

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Providing information about clinical efficacy and potential cost offsets helps make the case for coverage expansion