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Evidence Gene-expression and wound-healing research support the matrix-remodeling mechanism

As a first-in-class dipeptidyl peptidase 1 (DPP1) inhibitor, BRINSUPRI targets neutrophilic inflammation by inhibiting neutrophil serine proteases, addressing a root cause of airway damage, persistent infections, and exacerbations in NCFB

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[17] [18] Patients should have thyroid function monitored during substantial weight loss, with dose adjustments based on TSH and FT4 results

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doi: 10.1590/fst.24219 79