The dual agonist approach represented by tirzepatide demonstrates that activating multiple complementary pathways produces superior results to targeting a single pathway, even when that single pathway works quite well on its own
But again, if you look at the bioavailability, its less than 1% and thats when its swallowed
10.3390/molecules27051750 25 JandhyalaS
Additionally, it is important to follow the instructions on the label of the supplement
The drugs efficacy in obese adolescents was also notable, with significant reductions in BMI and higher proportions achieving over 5% and 10% weight loss compared to placebo [38]
There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis associated with GLP-1RA use compared to usual care