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Impact of metformin use and diabetic status during adjuvant fluoropyrimidine-oxaliplatin chemotherapy on the outcome of patients with resected colon cancer: a TOSCA study subanalysis
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Treatment interruptions may occur due to medication shortages, side effects, surgical procedures, financial constraints, or personal circumstances
The trial was small and short, and the participants were predominantly already taking metformin (some with a sulfonylurea) alongside diet and exercise, which makes it hard to isolate the probiotic's specific contribution
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