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However, some outcomes, like muscle gain, may take more time
Recently, we found that semaglutide therapy post-stroke can prevent ischemia-induced neurotoxicity and normalize neurogenesis and proliferation of stem cells in the brain via inhibition of p38 MAPK/MKK/c-Jun activity, regulation of Bcl-2/Bax pathways, and C-raf/ERK/caspase-3, restoration of insulin signaling sensitivity, and normalization of the ERK1 and IRS1 pathways (120)
The dose will continue to rise slowly
This schedule aims to reduce stomach side effects while appetite signals adjust
There was no plateau, and in fact it appears longer term trials will probably easily clear 20% weight loss, especially if metformin and/or SGLT2i medications are added on as these can both add another 2-3% extra weight loss when combined with a GLP-1 medication
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