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However, native GLP-1 is rapidly degraded in the body by an enzyme called dipeptidyl peptidase-4 (DPP-4), which limits its therapeutic use
Clinical trial data from the STEP trials for semaglutide reported constipation in approximately 11-24% of participants, depending on the dose, compared to 11% in placebo groups
Bae HC, Park HJ, Wang SY, Yang HR, Lee MC, Han HS
Because of its safety profile and the lack of serious side effects, magnesium is often chosen as a preventive strategy either alone, or with other preventive medications. Magnesium has shown results in both maintenance doses and for acute onset treatment and relief
Argenx is running Phase 3 studies of empasiprubart, which acts at a different point in the cascade
Serious instances, such as chronic vomiting, dehydration, acute abdominal pain, or symptoms of pancreatitis, require immediate attention
