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Biochemically, it is marked by disrupted iron metabolism, accumulation of lipid hydroperoxides (LPO), and depletion of intracellular glutathione (GSH)
It is not a single compound and not a pharmaceutical product
Its safety profile is generally favorable, but several specific considerations deserve clinician attention particularly around copper biology, zinc balance, and the small number of patient populations where caution or contraindication applies
j is the effect of LPS or H 2 O 2 (j = 1 or 2)
Hadamard editing of glutathione and macromolecule-suppressed GABA
Traditional antioxidant therapy may benefit from a complementary approach from emerging dietary patterns like the MD, rich in polyphenols and flavonoids such as quercetin and kaempferol, which exhibit strong anti-inflammatory and antioxidant effects [49]
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