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Weight loss with Tesofensine was primarily fat mass, with a notable preservation of lean mass as assessed by DEXA. Astrup et al., The Lancet May Improve Training Drive and Mood Elevated dopamine and norepinephrine levels can enhance motivation , focus , and mental resilience during challenging cutting phases

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(PubMed) Zhang S, Hunter DJ, Forman MR, et al

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Other research has also shown a tie between growth hormone and better mental capacity, memory, and mood