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The studys results provide insights into some known and previously unrecognized benefits and risks of GLP-1RA that may be useful to inform clinical care and guide research agendas. Potential Downsides to GLP-1s Al-Aly emphasizes that his study also highlighted potential downsides to the medications, including an increased risk of gastrointestinal problems such as nausea, vomiting, diarrhea, and in rare cases paralysis of the stomach

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Researchers and clinicians do not fully understand the mechanisms behind these disturbances

Oral GLP-1s may still need to overcome perceptions that tablets are less effective or less medically credible than injections

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8 , e2457349 (2025)