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Nature PubMed Preclinical literature and narrative reviews describe pleiotropic actions including angiogenesis modulation (promotion in healing contexts and proposed inhibition in rodent corneal neovascularization models) and purported cytoprotective effects across diverse injury paradigms, but these remain unconfirmed in controlled human experiments

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By the time youve reached 55, levels have typically dropped to one-tenth of the amount they were during puberty

The mode of NOX-2 inhibition seems to stem from an inhibition of platelet-derived growth factor (PDGF)-mediated NAD(P)oxidase activation (Ten Freyhaus et al., 2006)