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The mechanism appears to be interference with erythropoiesis

Red Blood Cell Formation: B12 is needed for making red blood cells, preventing anemia and ensuring oxygen delivery

Specific symptoms documented included diarrhea, flatulence, nausea, and increased appetite

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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent