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Key secondary endpoint: Change in body weight from baseline to Week 26
People can lose weight on Ozempic, but safety remains a concern especially when used off-label
Bariatric surgery produces significant weight loss (25 to 30% average) but carries surgical risks and requires permanent lifestyle modifications
Bupropion-naltrexone (Contrave) reduces hunger signals in the brain
GLP-1 RAs primarily work via appetite suppression and the resulting caloric restriction induces muscle loss which is likely the result of mechanisms that evolved to promote survival during periods of food scarcity
Stop liraglutide and start dulaglutide 0.75 mg weekly with the same one-week interval
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