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Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats
It's important to emphasise that GLP-1 receptor agonists are not licensed specifically as lipid-lowering therapies, though they may have beneficial effects on cholesterol as part of their overall metabolic impact
Inhibiting the expression of inflammatory factors and fibrosis mediators and regulating intestinal microbiota may be the potential mechanisms of these two drugs to delay the progression of DKD
Most challenges have solutions if addressed proactively
And insulin sensitivity improves across the board
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