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Heres how long injection site soreness can last for common vaccines: COVID-19 vaccine or booster: 1-3 days Influenza vaccine: 1-2 days Varicella vaccine: 1-3 days Pertussis vaccine: 1-3 days MMR Vacine: 1-3 days Pneumococcal vaccine: 1-3 days RELATED: Can you get the flu from the flu shot

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