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Record symptom timing: note what changed before sleep worsened

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This biphasic response reflects the dual role of ROS in TGF- regulation: moderate ROS activate latent TGF- complexes and promote Smad phosphorylation via redox-sensitive kinases such as p38 MAPK and JNK, whereas excessive ROS inhibits TRII and Smad3 phosphorylation 72

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The difference between group I and II was established by the presence or absence of dyslipidemic status, as a risk factor, associated with cardiac pathology