Chen S, Luo Y, He Y, Li M, Liu Y, Zhou X, et al
Published online November 24, 2025
Real-world impact of adding a glucagon-like peptide-1 receptor agonist compared with basal insulin on metabolic targets in adults living with type 2 diabetes and chronic kidney disease already treated with a sodium-glucose co-transporter-2 inhibitor: the impact GLP-1 CKD study
While these medications work through entirely different mechanismstirzepatide as a dual GIP/GLP-1 receptor agonist reducing appetite and orlistat as a lipase inhibitor blocking fat absorptionthere is no clinical trial data specifically evaluating their combined use
Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A
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