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Reduced electron flow through complexes I and III slows downstream OXPHOS, leading to substrate accumulation and impaired metabolic flexibility ( AMP-activated protein kinase (AMPK) plays a critical but context-dependent role in this process ( 4.2 m disruption hinders FA transport During the progression of HF, the stability of the m is essential for facilitating the transmembrane transport and oxidation of fatty acids

Visual changes: subtle improvement in abdominal definition, slightly more visible obliques, mild reduction in lower abdominal "pouch." These changes are visible to the individual but unlikely to be noticed by others

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BD FACSDiva and Bio-Rad Everest were used to collect FACS data