Insulin dose reduction of 20 to 50% at triple agonist initiation is consistent with the approach used in tirzepatide trials: the SURPASS-5 trial (N=475) reduced insulin glargine by 20% at tirzepatide initiation, which reduced hypoglycemia without sacrificing glycemic control
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Moreover, reducing tumor lactate levels inhibits Kla and disrupts the lactate metabolic balance in the TME, representing a promising cancer treatment option that has already been implemented in several preclinical and clinical trials
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Materials and methods Experimental animals and establishment of obesity model This study utilized 8-week-old male Wistar rats (220 20 g) from Beijing Vital River Laboratory Animal Technology Co