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Glioma stem cells show a decrease in SAM and, therefore, in methionine

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Alyftrek met that endpoint, and on the key secondary endpoint of sweat chloride reduction, it demonstrated superiority: in SKYLINE 102, sweat chloride decreased by 7.5 mmol/L with Alyftrek versus an increase of 0.9 mmol/L for Trikafta

The responsible clinical approach is to titrate slowly, evaluate response at each stage with monitoring, and stop increasing when results are adequate rather than when the theoretical maximum has been reached