Dehydration that wont budge
Orforglipron showed similar gastrointestinal side effects as other GLP-1 drugs, with the most common being diarrhea, nausea, indigestion, and constipation
Journal of Nutrition & Intermediary Metabolism 6 , 815, (2016)
Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy
So then there's other thing that's metabolized into is methanol
People with lower CYP1A2 activity may generate reactive aflatoxin metabolites more slowly (could be a good thing), but they can still be vulnerable if downstream conjugation pathways (GSTs, UGTs) are also compromised.[ref] Related article: CYP1A2 Gene: Fast or Slow Caffeine Metabolizer and More CYP3A4 and aflatoxin G1 / other mycotoxins: CYP3A4 is involved in the metabolism of aflatoxin G1 and many other compounds, including medications