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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility
2024;187(14):360218 e20
Bacteriostatic water (0.9% benzyl alcohol) is standard for multi-use vials
Missing items were replaced by multiple imputations and multivariate regression
La variabilidad gentica puede jugar un papel en la respuesta al tratamiento, aunque actualmente no existen pruebas farmacogenmicas validadas para predecir la respuesta a estos medicamentos en la prctica clnica
GLP-1RAs stimulate insulin secretion and suppress glucagon secretion, which may modify cardiac energy metabolism in T2DM patients [103]
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