The evidence hierarchy runs: prescription GLP-1 medication (strongest), oral supplements at studied doses (modest), dietary changes supporting natural GLP-1 (helpful), adhesive patches (zero evidence)
J Agric Food Chem 67:1004810058
After 52 weeks, HbA1c was reduced by 0.4% (4 mmol/mol) by vildagliptin and 0.5% (5 mmol/mol) by glimepiride, body weight was slightly reduced by vildagliptin (0.2 kg) but increased by glimepiride (1.89 kg) and there was a 10-fold higher incidence of hypoglycemia in the glimepiride group
Per-arm enrollment: 56% of sub-study participants were female
It means your body needs time to adjust to the new medication
236 The oxidation cycle of both Prxs and GSH is directly influenced by the availability of redox cofactor NADPH, suggesting that NADPH metabolism might play a vital role in controlling redox rhythmic and transcriptional oscillations