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However, it also turns out to be true that, under normal conditions, dietary intake of glutathione does not allow its direct use: since it is a tripeptide, enzymes in the gastric juices would break it down into its constituent amino acids, forcing our body to consume energy to synthesize it from scratch
Inflammation-, immunothrombosis,- and autoimmune-feedback loops may lead to persistent neutrophil self-stimulation in long COVID
**Rare Blood Disorders**: In extremely rare cases, high doses of glutathione may lead to blood disorders such as hemolysis, especially in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency
These effects typically resolve with consistent use
This explains why glutathione depletion has been implicated in central nervous system disorders, cardiovascular diseases, diabetes complications, liver diseases, HIV infection, tuberculosis, and even poor outcomes in viral illnesses such as COVID-19, as highlighted in multiple reviews including Guloyan et al., 2020
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