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There is also ongoing debate about the most suitable product categorywhether food, supplement, or drugand about how to standardize measures of potency, viability, and functional outputs for strains whose benefits may vary significantly depending on context, including baseline microbiome, diet, and host genetics

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Single-dose use is also fine for occasional energy support

An OA mouse model was successfully established by injecting monosodium iodoacetate (MIA) in mouse knee joints 25 , specifically, involving anesthetic administration with 1.25% tribromoethanol (Bimake, M2920) at a dose of 0.2 mL/10 g body weight, followed by intra-articular injection of 10 L MIA (50 mg/ml, Sigma-Aldrich, 57858-25G-F) into the right knee joint using a 30-gauge needle

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