Vials are assembled into multi-vial research kits that can be reconstituted with a suitable sterile diluent immediately before use in line with internal SOPs
3 News-Medical / Metabolic pressCoverage of the AOD-9604 Phase 2b obesity trial outcome (development discontinued ~2007)
We start with a 1,000 mcg injection every week to quickly fix the deficiency
Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake
In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]
By carefully following sterile technique, rotating injection sites, and disposing of supplies safely, youll reduce risks and make the process as comfortable as possible
