These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition or disease
Loading phases may use higher doses for 4-6 weeks, followed by maintenance therapy
Advances in structural biologyparticularly the integration of AlphaFold and RoseTTAFoldhave enabled rational drug design targeting key ferroptosis effectors such as ACSL4, LOXs, and system Xc components
doi: 10.3389/fnut.2022.1023997 100
This has shifted the conversation somewhat, and off-label longer-term use is becoming more common in obesity medicine
Daily targets: Sodium: 2,500-3,000mg with medical guidance Potassium: 4,700mg or more with medical monitoring Magnesium glycinate: 350mg supplemental (upper limit) Calcium citrate: 1,000-1,200mg supplemental (divided doses) Vitamin D: 2,000 IU daily Oral rehydration solution (ORS): As needed after each episode of fluid loss Implementation: Sip ORS continuously throughout the day Small frequent electrolyte doses rather than large single doses Bone broth as tolerated between meals Magnesium and calcium in divided doses to maximize absorption Daily symptom tracking including fluid intake, urine color, and episodes of vomiting or diarrhea Contact provider if unable to keep fluids down for more than 24 hours If you are on Protocol 3, talk to your healthcare provider about whether a dose adjustment is appropriate
