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However, currently the use of GLP-1 RAs is not recommended as treatment of MASLD.(3) The American Diabetes Association 2025 guidelines similarly state GLP-1 RAs are recommended in adults with diabetes, obesity, and MASLD in combination with diet and exercise for weight loss

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Across both groups, people who took orforglipron also saw lasting improvements in key health markers, including blood sugar, blood pressure, insulin, and cholesterol levels

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According to the World Health Organization, a person is considered obese if their body mass index (BMI) is 30 kg/m 2 or greater