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FEV 1 /FVC: betaine, p value = 2.87 10 4 ), 16 microbial-derived metabolites were associated with significant increases in exacerbations, including phenylacetylglycine, indoxyl sulfate, kynurenate, and quinolinate ( p values = 6.66 10 10 , 1.28 10 9 , 8.67 10 9 , and 3.69 10 8 , respectively)

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