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Injectable GLP-1 medications such as Wegovy and Zepbound became popular because they helped many patients lose significant weight without surgery

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The index date for this group corresponded to the initial date of their obesity diagnosis

First publicly identified around 2019, retatrutide has generated significant attention in the medical community after demonstrating unprecedented weight loss results in clinical trialswith participants losing up to 24.2% of their body weight in 48 weeks, surpassing the efficacy of current market-leading medications like semaglutide (Wegovy) and tirzepatide (Mounjaro)

Gastrointestinal side effects were most prevalent during the dose-escalation period the weeks during which the dose is gradually increased towards the target maintenance level