ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)
Developability remains a key challenge, but emerging approaches, such as the technology stack we are developing at SynX, are poised to unlock this modality to become much more widely deployed
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Vitamin B12 plays an essential role in red blood cell formation, nerve function, and overall metabolism
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