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Some also report pelvic weakness that reflects muscle loss rather than direct GLP-1 action

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doi: 10.1016/S0140-6736(08)61206-4 167 UmapathysivamMMLeeMYJonesKLAnninkCECousinsCETrahairLGet al

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Updated multi-society guidance aligns with broader recommendations which prioritize individualized risk factors for aspiration and other complications, rather than dosing frequency alone

Nausea occurred in 46.6% of patients on oral semaglutide versus 18.6% on placebo, while vomiting affected 30.9% versus 5.9%