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Most chronic diseases of the CNS are associated with loss of function of astrocytes, and such loss of function is emerging as a leading mechanism of disorder-related neurological dysfunctions ranging from mild changes in synapse regulation to potential overt neurotoxicity in extreme cases

Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinsons disease

Hedonic eating, driven by pleasure and reward, also decreases as cagrilintide modulates the dopaminergic pathways involved in food reward

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Tesamorelin stimulates growth hormone release and has FDA approval for HIV-associated lipodystrophy