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The higher pH protects the peptide from pepsin degradation, which requires acidic conditions

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More recent clinical research suggests it may help reduce symptom burden in perimenopausal women, including hot flashes, stress, and overall quality-of-life measures.83 84 85 However, most of the available data comes from a relatively small number of clinical trials, and its mechanisms are not yet fully understood

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The Bottom Line Theres a clear association between lower B12 levels and a higher body-weight