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Porter, K

For the polyglutamylation to be effective and to achieve tissue retention, 5-methyl-THF needs to be first metabolized to THF via the methionine cycle

doi: 10.1073/pnas.1919048117 Improving the assessment of mild cognitive impairment in advanced age with a novel multi-feature automated speech and language analysis of verbal fluency Chen L et al

Mavigner M, Raper J, Kovacs-Balint Z, Gumber S, O'Neal JT, Bhaumik SK, Zhang X, Habib J, Mattingly C, McDonald CE, Avanzato V, Burke MW, Magnani DM, Bailey VK, Watkins DI, Vanderford TH, Fair D, Earl E, Feczko E, Styner M, Jean SM, Cohen JK, Silvestri G, Johnson RP, O'Connor DH, Wrammert J, Suthar MS, Sanchez MM, Alvarado MC, Chahroudi A

Heres what we recommend for elderly patients: Start with 1000 mcg of vitamin B12 weekly for 4-6 weeks Then, give 1000 mcg every 1-3 months, depending on how theyre doing Keep an eye on their vitamin B12 levels, blood counts, and brain function A study in the Journal of Gerontology stressed the need for B12 in older adults

A meta-analysis of 13 clinical trials that included 421 patients with stage 25 CKD who did not require dialysis found that up to three months of exercise therapy resulted in a significant increase in eGFR compared with no exercise intervention