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Efficacy and tolerability of a skin brightening/anti-aging cosmeceutical containing retinol 0.5%, niacinamide, hexylresorcinol, and resveratrol

Both products are available in our catalog, both are widely studied in the anti-aging research space, and both have distinct advantages depending on the research protocol

Ethics declarations Ethics approval All experiments were approved by the local authority veterinary service and by our institutions (University of Trieste, SISSA) authorities and performed in accordance with the Italian law (decree 26/14) and the UE guidelines (86/609/CE, 2007/526/CE, and 2010/63/UE)

Procedure Preheat spectrophotometer/microplate reader for 30 minutes, adjust the wavelength to 412 nm, set zero with distilled Preheat Reagent II in 37 (mammal cell) or 25 (other species) water bath for 30 Blank tube determination: take micro glass cuvette, add 20 L of distilled water, 140 L of Reagent II, 40 L of Reagent III in turn, mix well, place for 2 minutes, and measure 412 nm absorbance AB

Sermorelin acts as a selective agonist at the GHRH receptor (GHRHR), a class B G-protein-coupled receptor expressed on somatotroph cells of the anterior pituitary

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