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Zhou L, Wang Y, Zhou M, Zhang Y, Wang P, Li X et al (2018) HOXA9 inhibits HIF-1alpha -mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation
This is the central mechanism most reviews focus on

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Engage in regular strength training and cardiovascular exercise