glp 1 small molecule A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency Identification of small-molecule GLP-1R agonists

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J Clin Endocrinol Metab (2020) 105:e1331e1343

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All chromatography buffers were prepared in Milli-Q Ultrapure water (MilliporeSigma, Burlington, MA) with 1015 mM Tris-HCl (Thermo Fisher Scientific) and 0.005% Polysorbate 80 (PS80) (Croda, Snaith, United Kingdom), and the indicated sodium chloride (NaCl) (Teknova, Hollister, CA) concentration and pH were adjusted with either 50% sodium hydroxide (NaOH) (Thermo Fisher Scientific) or 37% hydrochloric acid (Thermo Fisher Scientific)