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The primary outcome was major kidney disease events, a composite of the onset of kidney failure, a sustained 50% reduction in eGFR from baseline, or death from kidney-related or cardiovascular causes
However, initial results vary significantly based on starting dose, individual metabolism, and baseline weight
Improper handling can reduce the medication's effectiveness or cause degradation
Meanwhile, problems with impulse control are central to addiction
Interestingly, GLP-1 receptors are also found on pancreatic delta cells, producing somatostatin, an inhibitory hormone, further dampening glucagon secretion (53)
Rushing the escalation increases GI side effects without necessarily producing faster appetite suppression
